What is nmn supplement? NMN is the “rejuvenating medicine” of the 21st century
Posted by GoodsOfJapan on
NMN is one of the components contained in vitamin B3 , and its official name is " nicotinamide mononucleotide ."
It is a substance that exists in humans and all living things and is naturally produced within the body, but it is thought that as it decreases with age, you will begin to notice various changes in your physical condition.
[Main effects of NMN]
・Activation of sirtuin (longevity) genes
・Rejuvenate your youthfulness
・Restores physical strength
・You can sleep soundly
・Rise in estrogen
-Easier breathing during exercise
・Skin texture improves
・Activation of mitochondria
・My head feels refreshed
- Improves thinking and concentration
・Metabolism increases
[Voices from patients who received NMN infusion]
・Spots and wrinkles are reduced, and skin feels rejuvenated
・Skin is smooth and shiny
・You can sleep soundly and wake up easily in the morning
・My body movements have improved and my physical strength has been restored.
- Improved concentration and work efficiency
- Blurred vision has been removed and you can now see clearly
- No more rough hands
・I have lost a little weight
This is a next-generation anti-aging therapy that has been discovered to have rejuvenating effects.
Experience the various effects for yourself.
"Sirtuin genes" extend healthy life expectancy
There are sirtuin genes that are known as ``longevity genes'' and ``rejuvenation genes.''
If this sirtuin gene can be activated, the number of mitochondria that produce energy sources in cells will increase, and abnormal proteins and old mitochondria in cells will be deleted and new cells will be reborn.
The sirtuin gene is expected to be a dream gene that can extend healthy lifespan.
It is said that by ingesting NMN, it is converted in the body into an in-vivo substance (NAD+) that decreases with age, activating sirtuin genes and slowing down the rate of aging.
|
get old |
does not age |
◆Aging is the “decline in physical function associated with aging.”
◆There are living things that do not age; it is not inevitable.
◆The latest research has revealed a way to control aging.
What is NMN (nicotinamide mononucleotide)?
NMN is a vitamin-like substance that is naturally produced in the body. However, as we age, the amount of NMN produced in the body decreases, and when NMN decreases in the body, aging begins, and it is thought that aging of physical and cognitive functions progresses.
Numerous studies have been published showing that ingesting NMN can bring about changes in the appearance and function of the body, and it is attracting attention around the world as a ``rejuvenating drug.''
Foods that contain a lot of NMN include edamame, broccoli, and cucumber, but in the case of broccoli, approximately 40 kg (approximately 2,000 bunches) of NMN is required to consume 100 mg of NMN per day.
・NMN is a precursor of NAD , a substance in the body that decreases with age.
・By maintaining its intracellular concentration, it is expected to maintain healthy body conditions.
・The amount of NAD is said to decrease to half of what it was in your 20s in your 50s .
・NMN is a substance that all humans naturally have in their bodies, and is also included in colostrum of breast milk and vegetables.
NMN is converted to NAD within cells and is used in two ways1
. Activates the longevity gene "sirtuin" (enzyme substrate)
NAD binds to and activates sirtuin (NAD is used in the deacetylation reaction of sirtuin). Humans and mice have seven types of sirtune genes (Sirt1-7).
NAD activates all seven types of sirtuins.
Sirtuins have four main functions:
① Control of epigenome (DNA repair. Sirt1, 6, 7)
② Control of energy metabolism (quality and quantity of mitochondria. Sirt 3, 4, 5)
③ Control of cell division (formation of egg cells. Sirt 2)
④ Clock inheritance such as Clock, Bmal1 NAD
also activates PARP:Poly (ADP-ribose) polymerase, etc.
2. Energy-producing (oxidation-reduction coenzyme)
It is an electron donor when producing energy (ATP) in the mitochondria.
All eukaryotic cells (animals, plants, and fungi) and most archaea and bacteria use NAD to make ATP.
ATP is the energy that all living things use to survive. NAD is an essential coenzyme to create ATP, and when NAD runs out, living things die.
NAD is an essential molecule for all animals to survive.
NMN is considered the most direct precursor of NAD.
Expected effects of NMN intake ( non-clinical )
A mouse experiment in which administration of NMN , a precursor of NAD , delayed the onset of various organ oxidation symptoms and aging diseases in mice.
| Effects of NMN administration/sirtuin factor activation |  |
Health benefits expected to be involved
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| body weight | Suppression of weight gain associated with aging (diet effect) | ||
| metabolism | Promotion of energy metabolism | ||
| activity | Increased physical activity | ||
| sugar metabolism | Increased insulin sensitivity | ||
| lipid | Improvement of lipid metabolism | ||
| muscle strength | Improvement of skeletal muscle mitochondria | ||
| aging |
Associated with aging in major metabolic tissues Suppression of gene expression changes |
||
| eye | Improving eye function and dry eye | ||
| Bone | Increased bone density | ||
| immunity | Improving immune cell numbers | ||
Expected to improve organs and functions that decline with age
NMN clinical research
1. Keio University: Safety confirmation
Professor Yutaka Ito and a research group at the University of Washington in the United States have revealed for the first time in the world that NMN can be safely administered to healthy humans .
Ten healthy men aged 40 to 60 years old took 100 to 500 mg of NMN three times at average intervals of two months. There were no changes in blood pressure or pulse, and tests to check the function of the liver and kidneys showed no abnormalities.
https://www.keio.ac.jp/ja/press-releases/files/2020/1/21/200121-1.pdf
2. Nippon Sport Science University: Exploratory exam
Targeted at young, healthy men, we performed cycling at an exercise intensity of 60% of maximum oxygen intake for 45 minutes, measured exhaled gas during exercise, and measured respiratory exchange ratio and energy substrate oxidation amount. Verified the changes that occur before and after NMN intake.
The results suggest that lipid metabolism improves during exercise .
https://life-is-long.com/article/423
3. Osaka University Hospital: Verification of effectiveness
We are currently researching the effects of NMN on physical frailty in diabetic men aged 65 and older .